The effect of factor XIII on endothelial barrier function was studied in a model of cultured monolayers of porcine aortic endothelial cells and saline-perfused rat hearts. The thrombin-activated plasma factor XIII (1 U/ml) reduced albumin permeability of endothelial monolayers within 20 min by 30 ± 7% (basal value of 5.9 ± 0.4 × 10−6 cm/s), whereas the nonactivated plasma factor XIII had

exchanged for the correct execution of a specified function without changing the XIII or the requirements regarding performance studies set out in Annex XIII. specific disorder, condition or risk factor of interest that it is intended to detect,

Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. NX_P00748 - F12 - Coagulation factor XII - Function. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis.

14C-Irbesartan (SR47436). av AE Fristorp · Citerat av 100 — xiii. Arne Sjölinder, min kollega och vän för språkgranskningen av manuset. Ett varmt tack till more active: if the ideational function of the grammar is `language as groups were characterised by a supportive atmosphere and a “fun-factor”. ENSG00000116815 ensHS ens Lymphocyte function-associated antigen 3 factor XIII B chain precursor (Protein-glutamine gamma- glutamyltransferase B 2 aug. 1995 — 1A.4.4 Human Factors, Heroic Acts, Errors of Commission ..

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The effect of factor XIII on endothelial barrier function was studied in a model of cultured monolayers of porcine aortic endothelial cells and saline-perfused rat hearts. The thrombin-activated plasma factor XIII (1 U/ml) reduced albumin permeability of endothelial monolayers within 20 min by 30 ± 7% (basal value of 5.9 ± 0.4 × 10−6 cm/s), whereas the nonactivated plasma factor XIII had

Specifically, factor XIII is likely involved in other aspects of wound healing, immune system function, maintaining pregnancy, bone formation, and the growth of new blood vessels (angiogenesis). Factor XIII is found both extracellularly in plasma and intracellularly in platelets, megakaryocytes, monocytes, placenta, uterus, liver and prostrate tissues.

F13A1 (Coagulation Factor XIII A Chain) is a Protein Coding gene. Diseases associated with F13A1 include Factor Xiii, A Subunit, Deficiency Of and Factor Xiii Deficiency.Among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Interleukin-4 and 13 signaling.Gene Ontology (GO) annotations related to this gene include protein-glutamine gamma-glutamyltransferase activity.

Contributions of many of its 37 amino B. Involvement of Factor XIII in Monocyte/Macrophage Function Since the discovery of FXIII-A in monocytes and macrophages in 1985 ( 8 , 130 , 257 ), its expression in various monocyte-derived mobile and fixed macrophages has been intensively studied and turned out to be a marker reaction for various subsets of these cells in physiological and Summary. Factor (F)XIII is a protransglutaminase that, in addition to maintaining hemostasis, has multiple plasmatic and intracellular functions. Its plasmatic form (pFXIII) is a tetramer of two pot Factor XIII, also known by the name fibrin stabilizing factor, is a key clotting factor in the coagulation cascade known for stabilizing the formation of a blood clot.

The gene for FXIII-B is located on chromosome 1 bands q32-32.1 and is 28 kb in size. 45 It contains 12 exons separated The activation peptide of blood coagulation factor XIII (AP-FXIII) has important functions in stabilizing the FXIII-A2 dimer and regulating FXIII activation. Contributions of many of its 37 amino B. Involvement of Factor XIII in Monocyte/Macrophage Function Since the discovery of FXIII-A in monocytes and macrophages in 1985 ( 8 , 130 , 257 ), its expression in various monocyte-derived mobile and fixed macrophages has been intensively studied and turned out to be a marker reaction for various subsets of these cells in physiological and Summary. Factor (F)XIII is a protransglutaminase that, in addition to maintaining hemostasis, has multiple plasmatic and intracellular functions.
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2020-03-23 Studies suggest that factor XIII has additional functions, although these are less well understood than its role in blood clotting. Specifically, factor XIII is likely involved in other aspects of wound healing, immune system function, maintaining pregnancy, bone formation, and … The well-known main function of factor XIII in blood consists in the stabilization of a formed thrombus by cross-linking of fibrin chains.

The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release.
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The effect of factor XIII on endothelial barrier function was studied in a model of cultured monolayers of porcine aortic endothelial cells and saline-perfused rat hearts. The thrombin-activated plasma factor XIII (1 U/ml) reduced albumin permeability of endothelial monolayers within 20 min by 30 ± 7% (basal value of 5.9 ± 0.4 × 10−6 cm/s), whereas the nonactivated plasma factor XIII had

Grundmann U, Amann E, Zettlmeissi G, Kupper HA. Characterization of cDNA coding for human factor XIIIa. Proc Natl Acad Sci USA 1986; 83 (21): 8024–8. Plasma factor XIII is a heterologous tetramer consisting of 2 A- and 2 B-subunits. The A-subunits contain the enzyme's active site, and the B-subunits serve a carrier function of the hydrophobic A-subunit in the aqueous environment of human plasma.

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Tissue-regenerating functions of coagulation factor XIII. Soendergaard C, Kvist PH, Seidelin JB, Nielsen OH. J Thromb Haemost, 11(5):806-816, 01 May 2013 Cited by: 11 articles | PMID: 23406195. Review

List of Figures. XVII. List of Tables. XVIII. List of Abbreviations. XX assessments of abdominal muscle function over time15 and factors such as relocation of. av K Shahgaldi · 2010 — assessment of cardiac function, 2D echocardiography has however several limitations xiii.

av O THOMAS · Citerat av 1 — Relevance of Factor XIII for epidural analgesia in the postoperative period, inhibitor and neuraxial blockade, for example, but platelet function

FORSSELL G.: Oversikt over resultaten av kr aftbehandling vid Radiumhemmet i. Stockholm and FORSSBERG A.: The time factor in the biological action of X-ray. I. Investiga- tion in general and on the function of the tin filter in special.

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